Universitaet Rostock
Universtitaetsplatz Rostock 15
18051 Rostock
Germany
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Prof. Dr. Gudio Hildebrandt Phone: +49 381 494 9000 Fax: +49 381 494 9002  Contact |
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Dr. Kathrin Manda Phone: +49 381-494-9110 Fax: +49 381-494-9002
Contact
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The University of Rostock is one of the oldest, traditional, comprehensive universities with a wide spectrum of scientific disciplines and a number of closely linked side institutes. The recently founded interdisciplinary faculty promotes an intensive cooperation between all faculties and highly efficient coordination of research activities.
Role of participant in research activities:
Investigation of radiation induced pro-inflammatory and pro-thrombotic changes in endothelial cells which may contribute to the pathogenesis of cardiovascular radiation injury at high or low dose rates. Especially radiation induced effects on RNA and protein expression of cytokines, adhesion molecules and pro-thrombotic surface proteins will be addressed.
Responsible scientists:
Dr. med. G. Hildebrandt is head of the Department of Radiation Oncology and head of the Radiobiological Laboratory. He has long-term experience in investigations of low dose radiation effects on inflammation (chronic, acute) in different species (human, rabbit, rat, mice) in vitro and in vivo
Previous experience relevant to tasks:
The radiobiology research group in the department of radiotherapy has extensive experiences in testing radiation sensitivity of various cell types after modification by different potentially chemotherapeutically active agents. A broad range of methods for characterizing radiation induced cell damage including irradiation and cell culture facilities, immunofluorescence microscopy as well as high throughput techniques like ELISA reader based assays are established and will prove very useful in the described project.
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